Prevention of diabetic nephropathy by sulforaphane: possible role of Nrf2 upregulation and activation. Greenberg, M. Journal of Agricultural and Food Chemistry, Nov. 14, 2007; vol 55: pp 9465-9469. Weisinger JR, Kempson RL, Eldridge FL, Swenson RS. Try to keep the water droplets away from the leaves while watering. A literature review reveals that the following group of people can misuse it: The review suggests that its easy availability, affordability, potent effects, favorable legal status, and natural origin may contribute to its misuse and addiction. Epub 2018 Jun 20. Other interactions: Taking magnolia bark with blood thinners, including aspirin, is not recommended. Ong CP, Lee WL, Tang YQ, Yap WH. PMID: 18426577; PMCID: PMC2359758. This is a rather serious disease that can lead to the death of the tree if left untreated. PMID: 31877856; PMCID: PMC7016989. 1999 Jun;33(6):1364-8. doi: 10.1161/01.hyp.33.6.1364. In traditional Chinese medicine, magnolia bark is considered to have antipyretic, analgesic, sedative, constipating, anti-asthmatic, cardioprotective, vasoprotective, or antibacterial properties. Chest pain or pressure. Spray the wound with copper fungicide and when it is dry, spray again with alcohol. However, no effective therapeutic method for obesity-associated kidney disease is available. If you decide to supplement with magnolia bark, carefully follow the manufacturers instructions regarding how much to take and how often. Data in humans are limited. Use of this Web site does not create an expressed or implied physician-patient relationship. The magnolia extract improved health issues such as anxiety, insomnia, depression, and libido. 2017 Mar.;18(3):194-214. Effect of honokiol on cytochrome P450 and UDP-glucuronosyltransferase enzyme activities in human liver microsomes. Furthermore, this research concluded that magnolia bark extract has two main components, magnolol and honokiol, responsible for this inhibitory effect against bacteria in the mouth. 2008 Apr 1;32(3):715-25. doi: 10.1016/j.pnpbp.2007.11.020. the contents by NLM or the National Institutes of Health. Can Magnolia Bark extract be used for getting rid of Bad Breath? Pillon NJ, Croze ML, Vella RE, Soulre L, Lagarde M, Soulage CO. Magnolia bark can also be toxic and has been linked to kidney disease and permanent kidney failure. 8 Health Benefits of Magnolia Bark + Dosage, Side Effects Here is a closer look at some of the potential benefits of magnolia bark. Shen Y, Pang EC, Xue CC, Zhao ZZ, Lin JG, Li CG. Call us at 833-347-1665 to make an appointment. Memorial Sloan Kettering does not assume any risk whatsoever for your use of this website or the information contained herein. Qualitative analysis for glomerular enlargement was indicated by mean glomerular area (c). One of the important jobs of the kidneys is to clean the blood. 1988 Jun 15;50(6):757-65. doi: 10.1016/0049-3848(88)90336-2. Anti-bacterial: helps against acne and itching. Various studies on honokiol support the use of this polyphenol in magnolia bark as a therapy for cancer treatment and prevention. Once cool, place the vessel overnight in a refrigerator allowing further extraction of petals. Design, Formulation and in vivo Evaluation of Novel Honokiol-Loaded PEGylated PLGA Nanocapsules for Treatment of Breast Cancer. Theoretically, magnolia might cause additive CNS depression and/or excessive bleeding when used perioperatively. Here are 15 herbs with powerful antiviral properties. Wounds on the trunk in which there is rotten wood. Therefore, magnolia bark could be used as a remedy for insomnia or simply to promote better sleep overall. A second study of the same magnolia and phellodendron bark extract in 56 adults observed that consuming 500 mg of the extract per day resulted in significantly lower cortisol levels and improved mood (25). Magnolia bark can also be toxic and has been linked to kidney disease and permanent kidney failure. The U.S. Food and Drug Administration (FDA) does regulate dietary supplements; however, it treats them like foods rather than medications. They also discovered that cortisol levels in the treatment group remained low in the evening and at bedtime. Additionally, a test-tube study found that magnolol inhibited the growth of lung cancer cells (21, 22). A clinical trial was conducted on overweight women aged between 20-50 years. This article lists 13 foods that have powerful anti-inflammatory effects to help lower chronic inflammation. Yet again, clinical studies in humans need to be conducted. Does dihydrohonokiol, a potent anxiolytic compound, result in the development of benzodiazepine-like side effects? 5) and concentrated under reduced pressure to obtain viscous dark-brown residue (360g, BL153). Urinary albumin and creatinine levels were examined to reflect renal function. Sesti G, Succurro E, Arturi F, et al. Biphenyl-type neolignans from, Shih HC, Hwang TL, Chen HC, et al. Epub 2008 Jun 26. Statements made about products have not been evaluated by the Food and Drug Administration. Chronic kidney disease - Symptoms and causes - Mayo Clinic 2005 - 2023 WebMD LLC, an Internet Brands company. However, Zhang et al. Front Neurol. Magnolia bark may cause kidney failure after long-term use. Kidney weight was normalized by tibia length (a). Magnolia bark is a popular herb in traditional Chinese and Japanese medicine. Sweet Magnolia: Tree Bark Extract Fights Bad Breath And Tooth Decay. ScienceDaily. Data in humans are limited. Yu-Chiang Lo, Teng Che-Ming, Chen Chieh-Fu, Chen Chien-Chih, Hong Chuang-Ye, Magnolol and honokiol isolated from magnolia officinalis protect rat heart mitochondria against lipid peroxidation. Phytomedicine. The medicinal use of this species is attributed to its different pharmacological effects, including anti-inflammation [11, 12] and antioxidative stress [13, 14]. Based on research in mice, some scientists believe that honokiol may help combat aging by increasing antioxidant enzymes and decreasing levels of methane dicarboxylic aldehyde (13). AltMedDex Consults: "Hou po -- Chinese herb mini-review.". Our data showed that BL153 administration did not affect HK II expression level in LFD group mice; moreover, BL153 administration in HFD group mice only increased HK II expression back to the normal level, even at a high dose (10mg/kg), indicating the safety of BL153, as illustrated in Figure 7. A number of anticancer mechanisms have been identified with magnolol. Suppression of, Semple RK, Crowley VC, Sewter CP, et al. These effects were enough for an introduction as a cosmetic material in moisturizers and face washes to alleviate irritated skin or manage skin diseases such as acne and atopic dermatitis. New botanical drug, HL tablet, reduces hepatic fat as measured by magnetic resonance spectroscopy in patients with nonalcoholic fatty liver disease: A placebo-controlled, randomized, phase II trial. 4-O-methylhonokiol attenuated. Both of them were significantly increased in HFD mice compared with LFD mice; however, this trend was partially abolished by BL153 treatment (Figure 3). Kim YJ, Choi MS, Cha BY, et al. Skin rash has been reported with the use of cosmetics containing magnolia bark extract. Taking magnolia bark along with drugs that promote sleep or treat anxiety, such as sedatives, sleep medications, and barbiturates, may cause drowsiness. However, all these structure alterations were alleviated after six months of BL153 treatment at a dose of 5mg/kg or 10mg/kg (Figure 2). Biol Pharm Bull. Cut all diseased foliage from the tree and collect the fallen leaves. The same study observed that the same dose increased REM (rapid eye movement) and non-REM sleep. Lastly, a study in rodents noted that a mixture of honokiol and magnolol caused antidepressant-like effects, including improvements in serotonin levels in the brain and reductions in corticosterone levels in the blood (26). Similar to honokiol, studies in animals have shown that magnolol may help control and suppress tumor growth in various organs. Protective effect of sulforaphane against oxidative stress: recent advances. However, no effective therapeutic method for obesity-associated kidney disease is available. There were no treatment-related effects in clinical observations, macroscopic or microscopic findings, hematological . The spots often have something like flakes on them. Severe canker infections can cause plant death. When taken together, the evidence conveys that magnolia bark extract may help with the psycho-affective symptoms of menopause. Excess stress is a common problem. Western blot assay were performed for measuring the oxidative damage including the accumulation of 3-NT (a) and 4-HNE (b). A white substance that resembles powder appears on the leaves. Inhibition of melanogenesis and antioxidant properties of magnolia grandiflora L. Flower extract. Some of the conditions that magnolia bark has traditionally been used to treat include asthma, anxiety, depression, stomach disorders, and inflammation ( 3, 4 ). If the gall has formed on a side branch, cut it off a little below this spot. Kalman DS, Feldman S, Feldman R, Schwartz HI, Krieger DR, Garrison R. Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial. Antimicrobial activity of phenolic constituents of Magnolia grandiflora L. J Pharm Sci. Magnolol and honokiol isolated from Magnolia officinalis protect rat heart mitochondria against lipid peroxidation. Antidepressant-like effects of the mixture of honokiol and magnolol from the barks of Magnolia officinalis in stressed rodents. Molecules. Magnolia bark extract has been tested in studies as an ingredient in chewing gum. Received 2013 Sep 19; Revised 2013 Oct 31; Accepted 2013 Nov 6. Magnolia Bark has been used for over 1,000 years in traditional Chinese Medicine without indications of safety concerns. Obesity is considered as a state of chronic low-grade systemic inflammation and oxidative stress, which interact with each other and cause a vicious circle, promoting the development of insulin resistance [19, 20]. Protective effect of the ethanol extract of, Oxidative Medicine and Cellular Longevity. kidney - English-Spanish Dictionary - WordReference.com The beneficial effects of magnolol on learning and memory abilities were reported to be associated with superoxide dismutase (SOD) restoration in a scopolamine-induced mouse model [26]. Additionally, kidney histopathological alterations in HFD-fed mice were mild at the end of experiment, such as glomerular enlargement and renal tubular epithelium damage. PMID: 20190404. In some studies, a treatment that contained magnolia lessened pain and constipation in people with a type of indigestion. Collect all of the fallen leaves around the magnolia. It usually affects older trees. Some researchers believe that these effects are due to honokiol, a natural compound in the bark. A second study in mice observed similar outcomes after administering honokiol, which also decreased the amount of time it took the mice to fall asleep and transition into non-REM sleep (28). The bark of Magnolia oficinalis has been used in traditional Chinese medicine for centuries to address anxiety and nervous tension and to promote sleep. Health supplements have been a passion of mine for over 10 years straight. Health-related information changes frequently and therefore information contained on this Web site may be outdated, incomplete or incorrect. However, long-term use is not recommended due to a lack of safety data. Also black necroses appear in the most severely affected places. Its important to note that the exact mechanisms through which the isolated compounds contribute to these effects are still being investigated. Curcumin and chronic kidney disease (CKD): major mode of - PubMed There is one limitation in our study. This review will focus on the clinically relevant inflammatory molecules that play a role in CKD . Weakness. More recently, using a high fat diet- (HFD-) fed mouse model, Kim et al. This article outlines an anti-inflammatory diet plan that is based on science. Although remarkably elevated in HFD-fed mice at the end of experiment, ACR was significantly reduced after administration with BL153 at the dose of 5mg/kg or 10mg/kg for six months (Figure 1). Additionally, the magnolol appeared to increase the number of times the mice woke up during sleep but decrease the length of time they were awake. Effect of a proprietary Magnolia and Phellodendron extract on weight management: a pilot, double-blind, placebo-controlled clinical trial. Bacterial blight damages the young leaves of many plants, including magnolias. The disease results in large growths on the tree that are much larger than the branch or trunk on which they are growing. J Ethnopharmacol. Lee, Y.J. After the studies, researchers found that the treatment group did not gain any weight as opposed to the placebo group. Try to keep your magnolia tree undamaged. Algal leaf spot is a disease that affects trees and shrubs with thin, leathery leaves. Furukawa S, Fujita T, Shimabukuro M, et al. Evaluation of short-term and subchronic toxicity of magnolia bark Magnolia bark extract can be found at most supplement retailers. (9 Effects on Males). Epub 2016 Oct 6. Clean the wound of dead tissue. Does Magnolia Bark have any interactions with other supplements? This not only includes brain disorders like Alzheimers disease but also conditions like stress, anxiety, mood disorders, and depression (23). Allergies. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. Magnolol induces apoptosis in MCF-7 human breast cancer cells through G2/M phase arrest and caspase-independent pathway. Shen JL, Man KM, Huang PH, Chen WC, Chen DC, Cheng YW, Liu PL, Chou MC, Chen YH. However, young trees can be severely damaged if the disease is noticed too late. Preclinical effects of honokiol on treating glioblastoma multiforme via G1 phase arrest and cell apoptosis. Magnolia officinalis (Hou Po) bark extract stimulates the Nrf2-pathway in hepatocytes and protects against oxidative stress. Modern research shows that it's helpful when treating various conditions like stress-induced anxiety, digestive issues . In traditional Chinese medicine, magnolia bark is often harvested by being peeled or cut away from the tree. Altern Ther Health Med. Some of the benefits of magnolia bark, such as improved sleep and mood, could be especially beneficial for women during menopause (30). PMID: 21311416. Can Magnolia Bark extract be used for Acne? Zhang GS, Wang RJ, Zhang HN, Zhang GP, Luo MS, Luo JD. J Neuroinflammation. Risks. Given the contradictory nature of studies and the available information, more human studies and clinical trials are required to establish the effects of magnolia bark on kidneys. Therefore, as long as magnolia bark is used responsibly, there do not appear to be many risks associated with its use. Moreover, our results showed that PGC-1 was slightly elevated in the kidney of HFD-fed mice. Boil 3 cups of water in a vessel and add about 2 cups of dry magnolia petals. A combination of honokiol and magnolol normalized biochemical abnormalities in brain 5-HT and 5-HIAA, serum corticosterone levels, and platelet adenylyl cyclase activity, a biomarker for depression in chronically stressed rodents(7). Insulin-induced hexokinase II expression is reduced in obesity and NIDDM. Spray the wounds with an aqueous fungicide solution. 19 Magnolia Bark Medicinal Uses (Kidney Failure Side Effects?) If wood decay progresses, use the services of a tree treatment company. In murine models, honokiol enhanced low-dose docetaxel treatment against prostate cancer growth and bone metastasis(37), and reduced breast tumor growth biomarkers(48). This makes sense, as its known that GABA(A) receptor activity is closely associated with sleep (29). The Best Supplements for Healthy Digestion, How to Get the Protective Power of Vitamin K, Lessen inflammation from rheumatoid arthritis, Improve heart health. Magnolia officinalis is a flowering herb that has been used in traditional Chinese medicine to treat anxiety, depression, stress, nervousness, and sleep-related problems. BL153 administration in an obese state attenuates kidney inflammation and oxidative stress, leading to improved renal pathological and functional alterations. Zhang J, Chen Z, Huang X, Shi W, Zhang R, Chen M, Huang H, Wu L. Insights on the Multifunctional Activities of Magnolol. n = 5; *P < 0.05 versus LFD group; # Xu et al. Cissus quadrangularis: Uses, Benefits, Side Effects, and Dosage, Galangal Root: Benefits, Uses, and Side Effects. Magnolol affects expression of IGF-1 and associated binding proteins in human prostate cancer cells in vitro. 2008 Apr 21;7:11. doi: 10.1186/1475-2891-7-11. No adverse effects related to magnolia bark or the compounds it contains have been observed. This research looked at both lab trails and human trails. However, all these alterations were attenuated by BL153 treatment, accompanied by upregulation of peroxisome proliferator-activated receptor- coactivator-1 (PGC-1) and hexokinase II (HK II) expression in the kidney. Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium. Often it will dry out on the stem and have a whitish color. Int J Mol Sci. Several distinct pathways through which insulin resistance and hyperinsulinemia lead to renal damage have been reported by overwhelming background studies, such as insulin-like growth factor 1 upregulation [4] and renin-angiotensin system activation [5]. doi: 10.1631/jzus.B1600299. Furthermore, our data suggested that the possible mechanism through which BL153 ameliorates renal inflammation and oxidative stress is PGC-1 and HK II upregulation in kidney. Luo J, Xu Y, Zhang M, Gao L, Fang C, Zhou C. Magnolol inhibits Lps-induced inflammatory response in uterine epithelial cells: magnolol inhibits Lps-induced inflammatory response. Magnolia Officinalis - an overview | ScienceDirect Topics Faint watery spots appear on the leaves at first. And use caution if you take medicine to help you sleep or lessen your anxiety. Nevertheless, magnolia bark appears to be a safe therapy that may help treat menopause symptoms. It has also been used as a sleeping aid. In summary, our results first demonstrate a therapeutic potential of BL153 in treating obesity-induced kidney disease. This result is significant as high cortisol levels have been strongly linked to high blood pressure. It is a disease that quite severely spoils the appearance of the bright green leaves of magnolia trees. In glioma cells, it induced autophagy and activated a p53/cyclin D1/CDK6/CDK4/E2F1-dependent pathway to induce apoptosis and cell cycle arrest(34) and in prostate cancer cells, honokiol suppressed c-Myc protein expression(30). Urine albumin (Bethyl Laboratories, Montgomery, TX) and urinary creatinine (BioAssay Systems, Hayward, CA) were measured according to the manufacturers' instructions. Honokiol is a potent scavenger of superoxide and peroxyl radicals. Magnolia Bark for Anxiety, Depression? - Ask Dr. Weil The bark is particularly rich in two neolignans that are believed to be responsible for its medicinal properties magnolol and honokiol (1, 2). However, after treatment with BL153, HK II expression was upregulated in HFD-fed mouse kidney, accompanied by renal oxidative stress alleviation. Spoto B, Mattace-Raso F, Sijbrands E, et al. All rights reserved. As blood moves through the body, it picks up extra fluid, chemicals and waste. Also, supplementation with magnolia bark is not recommended in pregnant and breastfeeding women. In human bladder cancer cells, it induced p27KIP1-mediated G2/M-phase cell cycle arrest to activate the extracellular signal-regulated kinase pathway(11), and decreased binding of transcription factor NF-kB to DNA to inhibit MMP9 expression(12). Epub 2007 Oct 20. Magnolia Bark Extract Uses, Benefits & Dosage - Drugs.com The nephrotic syndrome: a complication of massive obesity. If you use magnolia bark extract directly on the skin, the best way is with a solubilizer such as Pentylene Glycol Natural. Our website services, content, and products are for informational purposes only. Such leaves usually die after a while. Shortness of breath. A study in 40 women ages 2050 found that taking 250 mg of magnolia and phellodendron bark extract 3 times a day resulted in greater relief of short-term and temporary anxiety than taking a placebo (24). Over time, this spot becomes increasingly pale until the tissue dies and a brown spot appears. PMID: 7310672. n = 5; *P < 0.05 versus LFD group; # Characteristic ndings include mild pro-teinuria, proximal tubular dysfunction, sterile pyuria,anaemia out of proportion to the degree of renal failure andsmall smooth kidneys.54Histology shows prominent intersti-tial brosis and tubular atrophy, with little cellular inltrationand mild glomerular damage. ), Pueraria Mirifica for Transgender Women? When there's a problem with the kidneys, whether it's kidney disease or kidney stones, avoiding or limiting certain foods in your diet may help improve kidne. Before supplementing with magnolia bark, check with your medical provider to discuss proper dosage levels and ensure theres no risk of potential interactions with any medications youre taking. Then turn off the gas. Magnolol induces apoptosis via inhibiting the EGFR/PI3K/Akt signaling pathway in human prostate cancer cells. In the present study, we explored the therapeutic potential of a magnolia extract (BL153) for. The ethanol extract of M. officinalis (BL153) was analyzed by HPLC to ensure mainly that it is containing 14.8% of 4-O-methylhonokiol, 14.2% of honokiol, and 12.0% of magnolol, which were in agreement with previously published data [42]. PMID: 22771461. Spray the leaves and petioles with an aqueous solution of copper fungicide. summary The bark, leaves, and. Introducing the aspect of non-pharmacological treatment of diabetes . That way, your doctor can check on any potential side effects or interactions with any medications. PMID: 15856410. Tell your doctor about any supplements you're taking, even if they're natural. Not enough is known to rate the safety of topical supplements with Magnolia Bark applied to the skin. Weisinger RS, Stanley TK, Begg DP, Weisinger HS, Spark KJ, Jois M. Angiotensin converting enzyme inhibition lowers body weight and improves glucose tolerance in C57BL/6J mice maintained on a high fat diet. In current study, we provide the first evidence that magnolia extract, BL153, attenuates obesity-associated renal structural and functional changes in an HFD-induced obesity mouse model. Tell your healthcare providers about any dietary supplements youre taking, such as herbs, vitamins, minerals, and natural or home remedies. Today we will look at the most common magnolia diseases and how to treat them. Currently, there are no official recommendations for magnolia bark dosage. Botanical medicine can be used to help forestall the need for dialysis by treating the causes and effects of renal failure, as . This makes it hard to set a standard dose. During the six-month feeding, body weight was measured every month, and the gavage volume was justified based on the body weight change. 2010;33(3):427-31. doi: 10.1248/bpb.33.427. Like most such diseases, the Algal leaf spot is most active in warm and humid weather. The extract of the bark of Magnolia trees (Magnolia officianalis) has been used for some 1,000 years in traditional Chinese and Japanese medicine for treatment of maladies ranging from asthma to depression to headaches to muscle pain. Shimomura I, Funahashi T, Takahashi M, et al. Aside from neolignans, more than 200 chemical compounds have been isolated from the tree (5). If the gall grows around the trunk, the sap flow can be interrupted and the tree will die. Minerva Ginecol. In addition, some research -- in humans and animals -- suggests magnolia may also be useful in these ways: Some research has suggested some other possible benefits for magnolia: It might also help treat or prevent: Supplement makers may suggest varying amounts of their product for different purposes. PMID: 10373217. Magnolia bark may alter the effects of drugs that affect the functioning of the cytochrome P450 enzyme. Many different plants are susceptible to this disease, including magnolias. Western blot assay were performed for measuring the expression of inflammatory cytokines and TNF- (a) and PAI-1 (b). This finding was supported by a previous human study in obesity and type 2 diabetes individuals [32]. Cut it very carefully to avoid damaging healthy tissue. The leaves and flowers from the tree are sometimes used as well. On the other hand, overexpression of HK II is involved in cancer cell proliferation and migration [35]. For example, 4-O-methylhonokiol, a novel compound isolated from Magnolia officinalis, prevents the development and progression of Alzheimer's disease by improving oxidative stress through a p38 MAPK-dependent pathway [25]. Data were collected from five animals for each group and presented as means SD. The pathogen enters the tree through damage (wounds, cracks, etc.). Cui W, Li B, Bai Y, et al. Walker JM, Maitra A, Walker J, et al. Magnolia officinalis is a flowering herb that has been used in traditional Chinese medicine to treat anxiety, depression, stress, nervousness, and sleep-related problems. 2013 Sep 11;4:130. doi: 10.3389/fneur.2013.00130. These findings might lead to the development of brands of gum that contain this ingredient. Symptoms are bark deformation in the place where the disease is developing. PMID: 8117323. Effect of a proprietary Magnolia and Phellodendron extract on weight management: a pilot, double-blind, placebo-controlled clinical trial. Furthermore, an animal study concluded that chronic treatment with magnolia bark extract has an antihypertensive effect. Biofactors. Magnolol in Magnolia Bark will stimulate corticosterone secretion which will likely cause problems if you are using steroid medication. Our scientists pursue every aspect of cancer researchfrom exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. In the present study, we explored the therapeutic potential of a magnolia extract (BL153) for treating obesity-associated kidney damage in a high fat diet- (HFD-) induced mouse model. Although this product is designed for pest control, it does a good job with powdery mildew as well. MG132 is a peptide aldehyde proteasome inhibitor and exerts its therapeutic effects by reducing the degradation of ubiquitin-conjugated proteins such as nuclear-factor-E2-related-factor-2 (Nrf2), an important transcription factor regulating cellular defenses against reactive oxygen species, through inhibiting activity of the subunits of the core particle of 26S proteasome [38]. The latter were blocked with 5% milk, followed by incubation with the following antibodies: TNF-, PGC-1 (Abcam, Cambridge, MA), PAI-1 (BD Bioscience, San Jose, CA), 3-NT (Millipore, Billerica, MA), 4-HNE (Alpha Diagnostic International, San Antonio, TX), HK II, -actin, and NQO1 (SantaCruz Biotechnology, Santa Cruz, CA). Magnolol elicits activation of the extracellular signal-regulated kinase pathway by inducing p27KIP1-mediated G2/M-phase cell cycle arrest in human urinary bladder cancer 5637 cells. Consistent with these reports, our present study found that inflammatory markers, like TNF- and PAI-1, and oxidative stress markers, like 3-NT and 4-HNE, were elevated in HFD-fed mice, accompanied by insulin resistance as we reported recently (Sun et al., unpublished paper). 2019 Dec 22;12(1):48. doi: 10.3390/cancers12010048. Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. Magnolol enhances adipocyte differentiation and glucose uptake in 3T3-L1 cells. These compounds, including magnolol and honokiol, have been studied extensively in recent years for their anti-inflammatory, anticancer, antimicrobial, and antioxidant benefits (1, 2, 4, 6, 7, 8). 2012 Mar 19;9:57. doi: 10.1186/1742-2094-9-57. Medicinal plants used for dermatological affections in navarra and their pharmacological validation.
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