Twenty percent of men who take Propecia see their sexual function diminish. CO2 keeps serotonin in check. Post-finasteride syndrome. At least 5-6 patients per year find their way to #UCLA_Andrology. Hence, it is mandatory to ask about patients histories of preexisting depression or sexual dysfunction before starting finasteride treatment. Episode 18. Post-Finasteride Syndrome (PFS) describes serious neurological, physical and sexual side effects that persist - and commonly develop - after discontinuation of the 5alpha reductase inhibitor finasteride (Propecia, Proscar, generics). I dont think its very responsible for dermatologists to use [finasteride] to combat hair loss. [O]ur results showed that [finasteride] treatment affected the expression of a number of accumbal proteins involved in key functional processes, such as regulation of GABAergic neurotransmission, as well as steroid and pyrimidine metabolism. Hi Gary, Sexual dysfunction and suicidal ideation that appears to result from [finasteride] are important adverse effects. Keep me posted if you like. I want to try a solution like HCG low dose: Now, remember the idea of the testosterone bell curve and damping effects (little testosterone, little growth, more testosterone, more growth, even more testosterone, reduced growth)? Challenge to fellow health professionals via Twitter: October 26, 2021. Should We Fear Hair-loss Medications? Keywords: This can lead to numbness in the penis and erectile and libido disorders, which are related to what happens in the brain. I think this is what we are seeing here. I will not prescribe finasteride to young men with MPB because of the potential side effects. Havent used this drug in over 7 years of practice except in very rare cases. Unable to load your collection due to an error, Unable to load your delegates due to an error. Up to 20 percent of subjects reporting persistent sexual dysfunction for six or more years after stopping the drug, suggesting the possibility that it may never go away. I have patients who come in to see me for sexual problems. Reacting To Joe Rogan Talk About Finasteride, DHT And Post - YouTube We aimed to determine the type and frequency of symptoms in men having long-term sexual and non-sexual side effects after finasteride treatment (a condition recently called post-finasteride syndrome, PFS) against androgenetic alopecia (AGA). Post-finasteride syndrome wasnt reported in clinical studies, but it has been reported since the drug was approved. But always do blood tests first to see what is really going on. I stop just about every patient that comes to me on this medication. An official website of the United States government. It's when you lose the regrown hair when you stop taking fin or something? I had no noticeable sides until sexual problems which started 3 weeks ago so I stopped. You do think that these hypothetical damages can be reversed ? DHEA potently increases androsterone levels, and that is how its thought to lower anxiety. By definition, the condition is characterized by sexual dysfunction, somatic symptoms, and psychological disorders that persist after cessation of finasteride treatment. SperlingProstateCenter.com, Aug. 30, 2018. Its always been a question in my mind: Was this a lingering drug effect, or are there other factors coming into play? Skin Appendage Disord. Thanks in advance. Patients should be informed of these risks, so that they can weigh the benefits of harms against treatment. Never mind mess with my precious and pleasant DHT. Low levels of these hormones increase glutamate and may account for the appearance of behavioural disorders such as anxiety, aggression, and cognitive dysfunction. I have patients ask about [finasteride] all the time and I always discuss the risks of sexual dysfunction at length but its amazing how many guys seem not to care. This is the first analysis, to our knowledge, of suicidality and psychological adverse events in association with finasteride in VigiBase, an international pharmacovigilance databaseThese findings could raise concern that younger men with alopecia may be especially at risk for suicidality compared with the general populationClinicians should pay greater attention to the psychological adverse effects of finasteride when prescribing them, especially in the younger population using the drug for hair loss. With that in mind, DHT can take anywhere from4 weeks to 2 years or more to recover(R). With a greater concentration of receptors, the organ becomes more sensitive to testosterone and at a certain point, paradoxically, that sensitivity may shut down. In my opinion, I do not recommend using finasteride for the treatment of hair loss as its side effects are more dangerous. Segment on German network WDRs Tricks of the Beauty Industry, June 30, 2021. Epub 2020 Jun 26. New Information about Post Finasteride Syndrome (PFS) October 2, 2016 At this year's ISHRS meeting in Las Vegas, Dr. Alan Jacobs a neuroendocrinologist at Duke University School of Medicine spoke on the topic of Post Finasteride Syndrome (PFS). Curr Urol Rep. 2018 Jun 16;19(8):65. doi: 10.1007/s11934-018-0814-z. The effects in the brain of finasteridehave been poorly explored. Post-finasteride syndrome: a surmountable challenge for clinicians: Fertility and Sterility, January 2020. Then, when people are coming back and saying they have libido issues, those are relevant. Epub 2016 Jan 13. Keeping it low, below 7ng/ml, is absolutely key to improving. We are certainly very cautious, because we see the side effects [of finasteride]. Statement (via Twitter) in response to Jagan Kansal, MDs tweet, Thoughts on propecia in young guys causing decreased libido, possibly permanent? November 6, 2020. Additional side effects of finasteride include: A low DHT state can lead to low dopamine (R), high estrogen (R), high prolactin (due to reduced dopamine), high cortisol (due to reduced clearance) (R), elevated serotonin (due to elevated estrogen and lower dopamine) and hypothyroidism (R). They have muted orgasms, reduced volume of ejaculate, reduced penile sensation If it is 1.4 percent [of finasteride patients who experience persistent sexual dysfunction] and there are several million people on this product, youre looking at 300,000 men rendered impotent by a hair-loss drug. Additional information on the Post-finasteride Syndrome as well as ongoing information about treatment options can be obtained at the PFS Foundation: https://www.pfsfoundation.org. [Propecia] is a scary drug and we have no idea who might be affected worse by it. PFSNetwork.org NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. Furthermore, finasteride inhibits CYP3A4 (which is the enzymes that detox finasteride) and that can cause a significant buildup of finasteride in the body over time. Differential Gene Expression in Post-Finasteride Syndrome Patients Palmitoylethanolamide (PEA) is a substance naturally produced in many cell types in our bodies, including in very high concentrations in our brains. [Propecia] has the sexual side effects, like erectile dysfunction, which can affect men for years. How do you explain that? Chronic insomnia , I am now taking Trazodone which helps me get to sleep, I also have myoclonic twitches and brain zaps while trying to fall asleep and my auditory system is super sensitive any small noise at night makes my me jump even when wearing ear plugs. The best sex strains. Thank you so much for your time. I just picked up Gaba, im assuming this is a good idea? [Y]ou need to understand that hair[-loss] is not a life-threatening condition. Many have never recovered sexual functioning, not worth the risk. Post-Finasteride Syndrome: Current Views and Where do We Stand? Do tests to see pregnenolone, progesterone, testosterone, DHT, thyroid (TSH, total and free T4 and T3, rT3), estradiol, estrone-sulfate and cortisol (both blood and 24h saliva). But be careful, friends. I didnt believe it either, until 10 years ago, when I started seeing more men with PFS I advise you once again to never use [finasteride] to treat hair loss. Even if the incidence of persistent sexual adverse events is 3% to 5%, which may be viewed as a small number, approximately 900,000 to 1.5 million men would suffer persistent sexual and psychiatric adverse events. Do you have any digestive issues? and transmitted securely. If topical finasteride causes severe neurocognitive problems, shouldnt we be quite worried about the millions getting the pill form? Yes TRT does seem to help people, but dont solve everything. Thus, it is inappropriate to dismiss this condition. Re: Post-Finasteride Syndrome: A Surmountable Challenge for Clinicians. The concept of PFS has emerged from reports of non-dermatologists, neuroendocrinological research and reflections, and uncontrolled studies of low quality and with a strong bias selection, while a significant nocebo effect among patients informed about possible side effects of finasteride is recognized. I would appreciate some specific help if you could get back to me. Post-Finasteride Syndrome Exists!! Yep, the medical system doesnt care about what happens to you. Just wanna ask advice from a casual weed smoker as in vaping on weekends what would be a good supplement/nutritional addition to counter any negative effects? Considering the thousands of sufferers who already have PFS, the scientific world immediately needs to conduct more research to determine how to effectively treat this horrible symptom complex. Many clinicians are unaware of the scope of the persistent physical and psychological adverse effects of finasteride while it is in usage and despite its discontinuation. When prescribing antidepressants, the advantages and disadvantages must be carefully weighed, as some antidepressants may improve the symptoms of depression but have an unfavorable effect on sexual function. Use of 5ARIs for treatment of AGA may lead to persistent sexual, genitourinary, physical, psycho-cognitive, and anti-androgenic sequelae even after cessation of 5ARI therapy Two subjects (8%) committed suicide during or after the study. Psychiatric Comorbidity Related to the Therapy of Male Androgenetic Alopecia Independent of the 5-Alpha Reductase Pathway. New evidence shows link between finasteride and suicidality Bring on the BIC! Post finasteride syndrome and adrenal fatigue can be interrelated. Now two months after stopping Dudasteride, my twitches and brain zaps are now greatly diminshed, insomnia is still a problem though. J Urol. Accessibility Since some of the effects of androgen inhibition cannot be reversed once local androgen levels are re-established, it is temping to speculate that patients could still suffer from adverse sexual effects several months or even permanently after finasteride discontinuation. [T]here has been a Red Hand Letter for this drug since 2018. Immunohistochemical Evaluation of Androgen Receptor and Nerve Structure Density in Human Prepuce from Patients with Persistent Sexual Side Effects after Finasteride Use for Androgenetic Alopecia: PLOS ONE, June 24, 2014. I added finasteride to my 2021 list of Drugs to Avoid. So thats all gone in many men, just because of finasteride. Love the site. What Is Post-Finasteride Syndrome? - GoodRx But Nobody Warned Me about Finasteride! These findings may prove crucial to understanding the neurochemical mechanisms of FINs neuropsychiatric side effects. HHS Vulnerability Disclosure, Help PFS can start shortly after starting the medication and can possibly last months to years after stopping. Unfortunately, some of the side effects of finasteride are more serious and persistent than the original condition it is intended to treat [W]e encountered a surprising association between finasteride use and presence of optic neuropathy or retinopathy To worsen the situation, the neuropsychiatric impact of finasteridechanges in mood and behaviorcan alter practitioner perceptions about affected patients, resulting in a psychosomatic diagnosis. Emotional Consequences of Finasteride: Fool's Gold - PubMed If cortisol is low in blood tests, then you can focus on increasing that, but if cortisol is low in saliva tests but high in blood tests, focus on calming the adrenals. It shows a much higher signal in comparison with other drugs used for alopecia or suspected to affect mood Im surprised the FDA has not done these simple comparisons to explore safety signals for finasteride. They also have problems with sex drive. I can definitely have a look for you and see if I find anything that needs optimization. Post-finasteride syndrome (PFS) is a constellation of serious adverse side effects manifested in clinical symptoms that develop and persist in patients during and/or after discontinuing finasteride treatment in men with pattern hair loss (androgenetic alopecia) or benign prostatic hyperplasia. Swiss TV network SRF, May 7, 2018. Observations performed in a subset of patients treated for male pattern hair loss indicate that persistent sexual side effects as well as anxious/depressive symptomatology have been reported even after discontinuation of finasteride treatment. PFS is realtime to re-evaluate its use. Eggs vs Whey protein: just stick to this one, Ashwagandha vs Shilajit: the best one for testosterone is, Maca vs tongkat ali: this one is better for libido. I Didnt Want to Go Bald. 5-R type 1, which creates the neurosteroids 5-DHP and allopregnanolone downregulate the glutamatergic system. Men reporting Post-Finasteride Syndrome experience side effects that persist after stopping finasteride or other 5-alpha reductase inhibitors. We do not capture any email address. 8600 Rockville Pike New Information about Post Finasteride Syndrome (PFS) Propeciahelp.com - Discussion forum for Post-Finasteride Syndrome MeSH As yet, the condition is not recognized by the medical community, although individuals who suffer from PFS present with relatively homogenous symptoms. Also I jumped the gun on TRT out of frustration and desperation. Doctors & Researchers Speaking Out - The Post-Finasteride Syndrome I got Post Accutane Syndrom, which is related to PFS, there is a down regulation of 5 alpha reductase 1. Blocking 5 alpha-reductase to any degree in the brain is a crapshoot. Do not take finasteride for hair lossDo not take finasteride for any purposeFor many years, Public Citizens Health Research Group has classified both [Proscar and Propecia] as Do Not Use because their benefits do not outweigh their adverse effects.
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